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In rodent studies, tirzepatide caused thyroid C-cell tumors

Allow a 14-21 day washout period before restarting any GH secretagogue protocol to ensure GHRH receptor density has returned to pre-cycle levels

Tirzepatide is a first-in-class dual incretin receptor agonist a single molecule that activates both the GIP (glucose-dependent insulinotropic polypeptide) and the GLP-1 (glucagon-like peptide-1) receptors, which is why it is often nicknamed a twincretin. [7] By engaging two incretin pathways it enhances glucose-dependent insulin secretion, promotes satiety, and delays gastric emptying, producing large effects on both glycemic control and bodyweight